Accumulation and effects of natural mixtures of persistent organic pollutants (POP) in Zebrafish after two generations of exposure.
Identifieur interne : 000264 ( Main/Exploration ); précédent : 000263; suivant : 000265Accumulation and effects of natural mixtures of persistent organic pollutants (POP) in Zebrafish after two generations of exposure.
Auteurs : Vidar Berg [Norvège] ; Jan L. Lyche ; Camilla Karlsson ; Benedicte Stavik ; Rasoul Nourizadeh-Lillabadi ; Nina H Rdnes ; Janneche Utne Skaare ; Peter Alestr M ; Elisabeth Lie ; Erik RopstadSource :
- Journal of toxicology and environmental health. Part A [ 1528-7394 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Cytochrome P-450 CYP1A1 (métabolisme), DDT (analyse), DDT (métabolisme), DDT (toxicité), Danio zébré (métabolisme), Danio zébré (physiologie), Facteurs sexuels (MeSH), Femelle (MeSH), Marqueurs biologiques (métabolisme), Maturation sexuelle (effets des médicaments et des substances chimiques), Modèles biologiques (MeSH), Mâle (MeSH), Poids (effets des médicaments et des substances chimiques), Polluants chimiques de l'eau (analyse), Polluants chimiques de l'eau (métabolisme), Polluants chimiques de l'eau (toxicité), Polychlorobiphényles (analyse), Polychlorobiphényles (métabolisme), Polychlorobiphényles (toxicité), Relation dose-effet des médicaments (MeSH), Sexe-ratio (MeSH), Surveillance de l'environnement (MeSH), Vitellogénines (métabolisme), Éthers de polyhalogénophényle (analyse), Éthers de polyhalogénophényle (métabolisme), Éthers de polyhalogénophényle (toxicité).
- MESH :
- analyse : DDT, Polluants chimiques de l'eau, Polychlorobiphényles, Éthers de polyhalogénophényle.
- effets des médicaments et des substances chimiques : Maturation sexuelle, Poids.
- métabolisme : Cytochrome P-450 CYP1A1, DDT, Danio zébré, Marqueurs biologiques, Polluants chimiques de l'eau, Polychlorobiphényles, Vitellogénines, Éthers de polyhalogénophényle.
- physiologie : Danio zébré.
- toxicité : DDT, Polluants chimiques de l'eau, Polychlorobiphényles, Éthers de polyhalogénophényle.
- Animaux, Facteurs sexuels, Femelle, Modèles biologiques, Mâle, Relation dose-effet des médicaments, Sexe-ratio, Surveillance de l'environnement.
English descriptors
- KwdEn :
- Animals (MeSH), Biomarkers (metabolism), Body Weight (drug effects), Cytochrome P-450 CYP1A1 (metabolism), DDT (analysis), DDT (metabolism), DDT (toxicity), Dose-Response Relationship, Drug (MeSH), Environmental Monitoring (MeSH), Female (MeSH), Halogenated Diphenyl Ethers (analysis), Halogenated Diphenyl Ethers (metabolism), Halogenated Diphenyl Ethers (toxicity), Male (MeSH), Models, Biological (MeSH), Polychlorinated Biphenyls (analysis), Polychlorinated Biphenyls (metabolism), Polychlorinated Biphenyls (toxicity), Sex Factors (MeSH), Sex Ratio (MeSH), Sexual Maturation (drug effects), Vitellogenins (metabolism), Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (metabolism), Water Pollutants, Chemical (toxicity), Zebrafish (metabolism), Zebrafish (physiology).
- MESH :
- chemical , analysis : DDT, Halogenated Diphenyl Ethers, Polychlorinated Biphenyls, Water Pollutants, Chemical.
- chemical , metabolism : Biomarkers, Cytochrome P-450 CYP1A1, DDT, Halogenated Diphenyl Ethers, Polychlorinated Biphenyls, Vitellogenins, Water Pollutants, Chemical.
- drug effects : Body Weight, Sexual Maturation.
- metabolism : Zebrafish.
- physiology : Zebrafish.
- chemical , toxicity : DDT, Halogenated Diphenyl Ethers, Polychlorinated Biphenyls, Water Pollutants, Chemical.
- Animals, Dose-Response Relationship, Drug, Environmental Monitoring, Female, Male, Models, Biological, Sex Factors, Sex Ratio.
Abstract
Effects of exposure to environmentally realistic mixtures of persistent organic pollutants (POP) harvested from aquatic ecosystems in Norway were studied in an in vivo zebrafish model. POP were extracted from burbot (Lota lota) liver from two separate lakes, Lake Losna and Lake Mjøsa, and exposed to zebrafish through the diet in a two-generation study. Effects on survival, growth, sex ratio, and timing of puberty were investigated. In addition, the biomarkers 7-ethoxyresorufin O-deethylase (EROD) and vitellogenin (Vtg) were measured. The ratios of contaminant levels in extracts collected from Lake Mjøsa:Lake Losna were 6, 10, and 270 for polychlorinated biphenyls (PCB), dichlorodiphenyltrichloroethanes (DDT), and polybrominated diphenyl ethers (PBDE), respectively. The concentration range of POP measured in zebrafish was lower than in burbot originating from Lake Mjøsa, but comparable to concentrations previously reported in humans and wildlife. The results showed that exposure to environmentally realistic mixtures of POP exerted a negative effect on survival of fish in both generations. The marked drop in survival during 9-20 days post fertilization (dpf) suggested that this period may be a critical window for development. In both generations an earlier onset of puberty was observed and a higher proportion of males than females was noted in exposed fish compared to controls. Suprising effects of exposure were found on body weight. In the first generation (F(0)), body weight was significantly higher in both exposure groups compared to controls, while in the next generation (F(1)) the same exposures were associated with a decrease in body weight. Zebrafish exposed to relatively low quantities of POP showed a significant induction of biomarkers (EROD and Vtg), while fish exposed to higher exposure doses did not demonstrate induction.
DOI: 10.1080/15287394.2011.550455
PubMed: 21391088
Affiliations:
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Lyche</name></author><author><name sortKey="Karlsson, Camilla" sort="Karlsson, Camilla" uniqKey="Karlsson C" first="Camilla" last="Karlsson">Camilla Karlsson</name></author><author><name sortKey="Stavik, Benedicte" sort="Stavik, Benedicte" uniqKey="Stavik B" first="Benedicte" last="Stavik">Benedicte Stavik</name></author><author><name sortKey="Nourizadeh Lillabadi, Rasoul" sort="Nourizadeh Lillabadi, Rasoul" uniqKey="Nourizadeh Lillabadi R" first="Rasoul" last="Nourizadeh-Lillabadi">Rasoul Nourizadeh-Lillabadi</name></author><author><name sortKey="H Rdnes, Nina" sort="H Rdnes, Nina" uniqKey="H Rdnes N" first="Nina" last="H Rdnes">Nina H Rdnes</name></author><author><name sortKey="Skaare, Janneche Utne" sort="Skaare, Janneche Utne" uniqKey="Skaare J" first="Janneche Utne" last="Skaare">Janneche Utne Skaare</name></author><author><name sortKey="Alestr M, Peter" sort="Alestr M, Peter" uniqKey="Alestr M P" first="Peter" last="Alestr M">Peter Alestr M</name></author><author><name sortKey="Lie, Elisabeth" sort="Lie, Elisabeth" uniqKey="Lie E" first="Elisabeth" last="Lie">Elisabeth Lie</name></author><author><name sortKey="Ropstad, Erik" sort="Ropstad, Erik" uniqKey="Ropstad E" first="Erik" last="Ropstad">Erik Ropstad</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1080/15287394.2011.550455</idno><idno type="RBID">pubmed:21391088</idno><idno type="pmid">21391088</idno><idno type="wicri:Area/PubMed/Corpus">000060</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000060</idno><idno type="wicri:Area/PubMed/Curation">000060</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000060</idno><idno type="wicri:Area/PubMed/Checkpoint">000061</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000061</idno><idno type="wicri:Area/Ncbi/Merge">000209</idno><idno type="wicri:Area/Ncbi/Curation">000209</idno><idno type="wicri:Area/Ncbi/Checkpoint">000209</idno><idno type="wicri:doubleKey">1528-7394:2011:Berg V:accumulation:and:effects</idno><idno type="wicri:Area/Main/Merge">000267</idno><idno type="wicri:Area/Main/Curation">000264</idno><idno type="wicri:Area/Main/Exploration">000264</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Accumulation and effects of natural mixtures of persistent organic pollutants (POP) in Zebrafish after two generations of exposure.</title><author><name sortKey="Berg, Vidar" sort="Berg, Vidar" uniqKey="Berg V" first="Vidar" last="Berg">Vidar Berg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway. vidar.berg@nvh.no</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Lyche, Jan L" sort="Lyche, Jan L" uniqKey="Lyche J" first="Jan L" last="Lyche">Jan L. Lyche</name></author><author><name sortKey="Karlsson, Camilla" sort="Karlsson, Camilla" uniqKey="Karlsson C" first="Camilla" last="Karlsson">Camilla Karlsson</name></author><author><name sortKey="Stavik, Benedicte" sort="Stavik, Benedicte" uniqKey="Stavik B" first="Benedicte" last="Stavik">Benedicte Stavik</name></author><author><name sortKey="Nourizadeh Lillabadi, Rasoul" sort="Nourizadeh Lillabadi, Rasoul" uniqKey="Nourizadeh Lillabadi R" first="Rasoul" last="Nourizadeh-Lillabadi">Rasoul Nourizadeh-Lillabadi</name></author><author><name sortKey="H Rdnes, Nina" sort="H Rdnes, Nina" uniqKey="H Rdnes N" first="Nina" last="H Rdnes">Nina H Rdnes</name></author><author><name sortKey="Skaare, Janneche Utne" sort="Skaare, Janneche Utne" uniqKey="Skaare J" first="Janneche Utne" last="Skaare">Janneche Utne Skaare</name></author><author><name sortKey="Alestr M, Peter" sort="Alestr M, Peter" uniqKey="Alestr M P" first="Peter" last="Alestr M">Peter Alestr M</name></author><author><name sortKey="Lie, Elisabeth" sort="Lie, Elisabeth" uniqKey="Lie E" first="Elisabeth" last="Lie">Elisabeth Lie</name></author><author><name sortKey="Ropstad, Erik" sort="Ropstad, Erik" uniqKey="Ropstad E" first="Erik" last="Ropstad">Erik Ropstad</name></author></analytic><series><title level="j">Journal of toxicology and environmental health. Part A</title><idno type="ISSN">1528-7394</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Biomarkers (metabolism)</term><term>Body Weight (drug effects)</term><term>Cytochrome P-450 CYP1A1 (metabolism)</term><term>DDT (analysis)</term><term>DDT (metabolism)</term><term>DDT (toxicity)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Environmental Monitoring (MeSH)</term><term>Female (MeSH)</term><term>Halogenated Diphenyl Ethers (analysis)</term><term>Halogenated Diphenyl Ethers (metabolism)</term><term>Halogenated Diphenyl Ethers (toxicity)</term><term>Male (MeSH)</term><term>Models, Biological (MeSH)</term><term>Polychlorinated Biphenyls (analysis)</term><term>Polychlorinated Biphenyls (metabolism)</term><term>Polychlorinated Biphenyls (toxicity)</term><term>Sex Factors (MeSH)</term><term>Sex Ratio (MeSH)</term><term>Sexual Maturation (drug effects)</term><term>Vitellogenins (metabolism)</term><term>Water Pollutants, Chemical (analysis)</term><term>Water Pollutants, Chemical (metabolism)</term><term>Water Pollutants, Chemical (toxicity)</term><term>Zebrafish (metabolism)</term><term>Zebrafish (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Cytochrome P-450 CYP1A1 (métabolisme)</term><term>DDT (analyse)</term><term>DDT (métabolisme)</term><term>DDT (toxicité)</term><term>Danio zébré (métabolisme)</term><term>Danio zébré (physiologie)</term><term>Facteurs sexuels (MeSH)</term><term>Femelle (MeSH)</term><term>Marqueurs biologiques (métabolisme)</term><term>Maturation sexuelle (effets des médicaments et des substances chimiques)</term><term>Modèles biologiques (MeSH)</term><term>Mâle (MeSH)</term><term>Poids (effets des médicaments et des substances chimiques)</term><term>Polluants chimiques de l'eau (analyse)</term><term>Polluants chimiques de l'eau (métabolisme)</term><term>Polluants chimiques de l'eau (toxicité)</term><term>Polychlorobiphényles (analyse)</term><term>Polychlorobiphényles (métabolisme)</term><term>Polychlorobiphényles (toxicité)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Sexe-ratio (MeSH)</term><term>Surveillance de l'environnement (MeSH)</term><term>Vitellogénines (métabolisme)</term><term>Éthers de polyhalogénophényle (analyse)</term><term>Éthers de polyhalogénophényle (métabolisme)</term><term>Éthers de polyhalogénophényle (toxicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DDT</term><term>Halogenated Diphenyl Ethers</term><term>Polychlorinated Biphenyls</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Cytochrome P-450 CYP1A1</term><term>DDT</term><term>Halogenated Diphenyl Ethers</term><term>Polychlorinated Biphenyls</term><term>Vitellogenins</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>DDT</term><term>Polluants chimiques de l'eau</term><term>Polychlorobiphényles</term><term>Éthers de polyhalogénophényle</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Body Weight</term><term>Sexual Maturation</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Maturation sexuelle</term><term>Poids</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Zebrafish</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytochrome P-450 CYP1A1</term><term>DDT</term><term>Danio zébré</term><term>Marqueurs biologiques</term><term>Polluants chimiques de l'eau</term><term>Polychlorobiphényles</term><term>Vitellogénines</term><term>Éthers de polyhalogénophényle</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Danio zébré</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Zebrafish</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>DDT</term><term>Halogenated Diphenyl Ethers</term><term>Polychlorinated Biphenyls</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>DDT</term><term>Polluants chimiques de l'eau</term><term>Polychlorobiphényles</term><term>Éthers de polyhalogénophényle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Environmental Monitoring</term><term>Female</term><term>Male</term><term>Models, Biological</term><term>Sex Factors</term><term>Sex Ratio</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs sexuels</term><term>Femelle</term><term>Modèles biologiques</term><term>Mâle</term><term>Relation dose-effet des médicaments</term><term>Sexe-ratio</term><term>Surveillance de l'environnement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Effects of exposure to environmentally realistic mixtures of persistent organic pollutants (POP) harvested from aquatic ecosystems in Norway were studied in an in vivo zebrafish model. POP were extracted from burbot (Lota lota) liver from two separate lakes, Lake Losna and Lake Mjøsa, and exposed to zebrafish through the diet in a two-generation study. Effects on survival, growth, sex ratio, and timing of puberty were investigated. In addition, the biomarkers 7-ethoxyresorufin O-deethylase (EROD) and vitellogenin (Vtg) were measured. The ratios of contaminant levels in extracts collected from Lake Mjøsa:Lake Losna were 6, 10, and 270 for polychlorinated biphenyls (PCB), dichlorodiphenyltrichloroethanes (DDT), and polybrominated diphenyl ethers (PBDE), respectively. The concentration range of POP measured in zebrafish was lower than in burbot originating from Lake Mjøsa, but comparable to concentrations previously reported in humans and wildlife. The results showed that exposure to environmentally realistic mixtures of POP exerted a negative effect on survival of fish in both generations. The marked drop in survival during 9-20 days post fertilization (dpf) suggested that this period may be a critical window for development. In both generations an earlier onset of puberty was observed and a higher proportion of males than females was noted in exposed fish compared to controls. Suprising effects of exposure were found on body weight. In the first generation (F(0)), body weight was significantly higher in both exposure groups compared to controls, while in the next generation (F(1)) the same exposures were associated with a decrease in body weight. Zebrafish exposed to relatively low quantities of POP showed a significant induction of biomarkers (EROD and Vtg), while fish exposed to higher exposure doses did not demonstrate induction.</div></front></TEI><affiliations><list><country><li>Norvège</li></country><region><li>Østlandet</li></region><settlement><li>Oslo</li></settlement></list><tree><noCountry><name sortKey="Alestr M, Peter" sort="Alestr M, Peter" uniqKey="Alestr M P" first="Peter" last="Alestr M">Peter Alestr M</name><name sortKey="H Rdnes, Nina" sort="H Rdnes, Nina" uniqKey="H Rdnes N" first="Nina" last="H Rdnes">Nina H Rdnes</name><name sortKey="Karlsson, Camilla" sort="Karlsson, Camilla" uniqKey="Karlsson C" first="Camilla" last="Karlsson">Camilla Karlsson</name><name sortKey="Lie, Elisabeth" sort="Lie, Elisabeth" uniqKey="Lie E" first="Elisabeth" last="Lie">Elisabeth Lie</name><name sortKey="Lyche, Jan L" sort="Lyche, Jan L" uniqKey="Lyche J" first="Jan L" last="Lyche">Jan L. Lyche</name><name sortKey="Nourizadeh Lillabadi, Rasoul" sort="Nourizadeh Lillabadi, Rasoul" uniqKey="Nourizadeh Lillabadi R" first="Rasoul" last="Nourizadeh-Lillabadi">Rasoul Nourizadeh-Lillabadi</name><name sortKey="Ropstad, Erik" sort="Ropstad, Erik" uniqKey="Ropstad E" first="Erik" last="Ropstad">Erik Ropstad</name><name sortKey="Skaare, Janneche Utne" sort="Skaare, Janneche Utne" uniqKey="Skaare J" first="Janneche Utne" last="Skaare">Janneche Utne Skaare</name><name sortKey="Stavik, Benedicte" sort="Stavik, Benedicte" uniqKey="Stavik B" first="Benedicte" last="Stavik">Benedicte Stavik</name></noCountry><country name="Norvège"><region name="Østlandet"><name sortKey="Berg, Vidar" sort="Berg, Vidar" uniqKey="Berg V" first="Vidar" last="Berg">Vidar Berg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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